Jason Boehme, MD

Dr. Boehme is a physician scientist at the University of California San Francsico. He completed medical school at the University of Iowa Carver College of Medicine and pursued his medical training at the University of California San Francisco where he did his pediatric residency followed by fellowship training in pediatric critical care medicine. During his fellowship training he joined the UCSF Pediatric Pulmonary Vascular Biology Research Group under the mentorship of Dr.’s Jeff Fineman and Emin Maltepe, where his scientific interest focused on the pathologic biochemical mechanisms initiating early pulmonary vascular dysfunction in congenital heart disease.

His fellowship research developed around the application of metabolomic methods to study pathologic biochemical phenotypes in the pulmonary arterial and pulmonary lymphatic vascular beds, leading increasingly to investigations of mitochondrial function as a central hub of metabolic derangements in pulmonary vascular dysfunction. This led to further collaborative scientific efforts and expanded evaluations of mitochondrial physiology and cellular redox biology as mechanistic links between abnormal pulmonary vascular hemodynamics and the progression of pulmonary vascular dysfunction in congenital heart disease. His current work is guided by an overarching hypothesis that endothelial mitochondria play an important role in the integration and transmission of proximal mechanotransductive signals within the pulmonary arterial endothelium and act as key mediators of hemodynamic vascular injury.